By Sun Hongmao

ISBN-10: 0081000987

ISBN-13: 9780081000984

This e-book will not be an exhaustive survey masking all points of rational drug layout. as an alternative, it's going to supply serious information via real-world examples. proper case reports might be offered and analyzed to demonstrate the subsequent: easy methods to optimize a lead compound even if one has excessive or low degrees of structural details; how you can derive hits from rivals’ lively compounds or from usual ligands of the goals; tips to springboard from opponents’ SAR wisdom in lead optimization; the best way to layout a ligand to intervene with protein-protein interactions via adequately interpreting the PPI interface; tips to sidestep IP blockage utilizing info mining; the best way to build and completely make the most of a knowledge-based molecular descriptor process; how you can construct a competent QSAR version via concentrating on information caliber and correct choice of molecular descriptors and statistical methods. A functional consultant to Rational Drug Design makes a speciality of computational drug layout, with in basic terms simple insurance of biology and chemistry matters, comparable to assay layout, goal validation and artificial routes.

  • Discusses various tactics appropriate to day-by-day drug layout
  • Readers can obtain the fabrics utilized in the ebook, together with constructions, scripts, uncooked info, protocols, and codes, making this publication compatible source for brief classes or workshops
  • Offers a distinct point of view on drug discovery study a result of author’s cross-discipline schooling background 
  • Explores the author’s wealthy reports in either pharmaceutical and educational settings

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A Practical Guide to Rational Drug Design by Sun Hongmao


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