By Gerd Hasenfuss,Hanjörg Just

ISBN-10: 364248672X

ISBN-13: 9783642486722

ISBN-10: 3798510474

ISBN-13: 9783798510470

Alteration of excitation-contraction coupling within the failing human middle was once deemed an enticing topic for a discussion among uncomplicated scientists and scientific researchers in continuation of prior Gargellen meetings excited by the functionality of the conventional and failing human myocardium. In 1987 easy mechanisms and scientific implications of then new insights into cardiac energetics used to be by means of a finished overview of inotropic stimulation and myocardial energetics in 1989. right here, we undertook a re-assessment of the rules of inotropic stimulation and of its capability healing price, in accordance with new observa­ tions from experiments with human myocardium. In 1992 the danger because of myocardial phenotype swap on account of model in middle failure used to be released. the following, adjustments of subcellular buildings and features due to persistent middle failure, summarized as phenotype switch, should be defined as an important attribute of the failing human myocardium. This subject used to be mentioned in higher intensity within the quantity "Cellular and Molecular adjustments within the Failing Human Heart", contemplating either the sarcolemma and the phosphodiesterases, in addition to excitation-contraction coupling and contractile proteins, extracellular matrix, and mitrochondrial function.

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Alterations of Excitation-Contraction Coupling in the Failing Human Heart by Gerd Hasenfuss,Hanjörg Just


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